Vortrag: "Modeling brain development in a dish: neurospheres for analyzing pathways to functions in a species-specific manner"

Sprecher: Prof. Dr. Ellen Fritsche, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf

Wann: Donnerstag, 30. März 2017, 12:15 Uhr

Wo: Campus der Medizinischen Fakultät, Haus 60b, 1. Etage, Konferenzraum der Klinik für Nieren- und Hochdruckkrankheiten, Diabetologie und Endokrinologie

Gastgeber: Prof. Dr. Peter Mertens (OvGU, Universitätsklinik für Nieren- und Hochdruckkrankheiten, Diabetologie und Endokrinologie)

Weitere Informationen: A major issue in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are needed to provide adequate experimental data that allow regulatory decisions. The Fritsche lab has developed a 3D method for DNT hazard assessment based on human, rat and mouse neurospheres that mimic early neurodevelopmental processes like neural progenitor cell (NPC) proliferation, migration, differentiation into neurons and glial cells as well as apoptosis in vitro. This system is thus suited to perform pathway-to-function analyses in a species-specific context. Such data is also valuable to translate rodent in vivo data to humans on a mechanistic basis within the Adverse Outcome Pathway (AOP) concept. The Fritsche lab focuses currently on the assay’s scientific validation in order to define its biological application domain. Furthermore, algorithms are developed for the analysis of neurospheres in medium-throughput Hight Content Imaging Analyses (HCA).

Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.