Veranstaltungen 2017
Vortrag: "Protective and pathogenic T-cell subsets in human autoimmune diseases"
Speaker: Dr. Jens Geginat, Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi«, Milano, Italy
Date: Thursday, 26th of October 2017, 5:00 pm
Location: Campus FME, Hörsaal Kinderklinik (Haus 10)
Host: Prof. Dr. Monika Brunner-Weinzierl (OvGU, Abteilung für Experimentelle Pädiatrie und Neonatologie)
Further Information: Dr. Geginat's main research interest is human T cell biology, in particular the characterization of regulatory and memory T-cell subsets. He has done relevant contributions to the understanding of how T cell memory is generated and maintained. Moreover, his group was recently the first to identify human IL-10 producing regulatory T cell subsets directly in vivo. The further characterization of these cells will clarify their role in immune-mediated human pathologies, and improve protocols for adoptive T cell therapy.
Vortrag: "Modulation of innate immunity by T. gondii virulence effectors"
Sprecher: Prof. David Sibley, Washington University, Division of Biology and Biomedical Sciences, USA
Wann: Mittwoch, 13. September 2017, 17:00 Uhr
Wo: Campus der Medizinischen Fakultät, Haus 22, Seminarraum 3
Gastgeber: Prof. Dr. Ildiko Dunay (OvGU, Institut für Inflammation und Neurodegeneration)
Weitere Informationen: Prof. Sibley's team studies the parasite Toxoplasma gondii as a model for intracellular pathogens that cause many of the world’s most debilitating infectious diseases. Toxoplasma is extremely widespread, infecting almost 25% of the human population. Although infections are normally benign, toxoplasmosis is an important pathogen in immunocompromised patients including newborns, elderly, and those with underlying immune deficiencies. The explore the molecular mechanisms whereby T. gondii disrupts host cell signaling and blocks immunity using a variety of cellular and molecular approaches. Furthermore they develop in vitro methods to cultivate and develop genetic tools in Cryptosporidium, a widespread cause of diarrheal disease in the developing world.
Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.
Vortrag: "A hostel for the hostile: The role of the bone marrow microenvironment in haematopoiesis and leukaemopoiesis and its therapeutic targeting"
Sprecher: Prof. Dr. Daniela Krause, Institut für Tumorbiologie und Experimentelle Therapie, Frankfurt
Wann: Donnerstag, 15. Juni 2017, 17:15 Uhr
Wo: Campus der Medizinischen Fakultät, Haus 10, Hörsaal Kinderklinik
Gastgeber: Prof. Dr. Berend Isermann (OvGU, Institut für Klinische Chemie und Pathobiochemie)
Weitere Informationen: Prof. Krause's group aims to target the bone marrow microenvironment as an adjunct to existing therapies. Haematological cancers have a high frequency amongst the general population and pose a major health care problem. Significant progress has been made in the treatment of leukaemia. The treatment of chronic myelogenous leukaemia (CML) was revolutionized by targeted therapy in the form of imatinib mesylate. However, targeted therapy is not curative and at least 61% of patients relapse when imatinib is discontinued. Rare quiescent leukaemia-initiating cells (LIC) or leukaemic stem cells (LSC) in CML and acute myeloid leukaemia (AML) appear to be resistant to tyrosine kinase inhibitors (TKIs) and other chemotherapeutic regimen, possibly due to LSC-protective effects by the BMM, leading to disease progression and relapse. Overall, the 5-year survival rate of adults with leukaemia is only 44%, and for adults with AML only 25% will live for 5 years. This warrants the search for novel, adjunct therapies.
Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.
Informationsveranstaltung zum Thema Acne inversa
Sprecher: Dr. med. Mareike Alter und Kirsten Zypro, Universitätshautklinik Magdeburg
Wann: Sonntag, 11. Juni 2017, 10:30 - 12:30 Uhr
Wo: Campus der Medizinischen Fakultät, Haus 10, Hörsaal Kinderklinik
Weitere Informationen: Acne inversa (Hidradenitis suppurativa) fordert oft Kraft, Zeit sowie Geduld. Sich gut mit der Erkrankung auszukennen ist ein erster wichtiger Schritt, um im Gleichgewicht mit ihr zu leben. Wir laden Sie herzlich ein, sich von Experten informieren zu lassen und sich zu den Themen auszutauschen, die Sie im Umgang mit der Erkrankung beschäftigen. Hier können Sie den Flyer zur Veranstaltung herunterladen.
Vortrag: "A TCR-Cholesterol Interaction controls phosphorylation of the TCR by Lck"
Sprecher: Prof. Dr. Wolfgang Schamel, Institute of Biology III (Molecular Immunology) and BIOSS Centre for Biological Signalling Studies, University of Freiburg
Wann: Donnerstag, 11. Mai 2017, 17:00 Uhr
Wo: Campus der Medizinischen Fakultät, Haus 10, Hörsaal Kinderklinik
Gastgeber: Prof. Dr. Burkhart Schraven (OvGU, Institut für Molekulare und Klinische Immunologie)
Weitere Informationen: The Schamel group uses biochemical and synthetic biology tools, in order to understand how the TCR transmits information across the plasma membrane. They could show that bivalent antigen-binding to the ectodomains of TCRαß induces a structural rearrangement at the cytoplasmic tails of CD3. This change is required for TCR activation and might expose these tails for interaction with cytoplasmic signalling proteins. Furthermore, they demonstrated that at least part of the TCRs are pre-clustered on the cell surface, and that this is involved in regulating the sensitivity of the T cell response. Currently, the group is rebuilding the pre-clustered TCRs in liposomes, in order to study the mechanisms of how these clusters form. Recently, they also started to employ systems biology approaches, to get a quantitative and dynamic understanding of the intracellular signalling network that is downstream of the TCR. Starting with the very upstream events, they discovered a novel mechanism with which T cells can discriminate between low and high affinity antigens.
Im Rahmen der gemeinsamen Seminarreihe des Sonderforschungsbereiches 854 und des Else Kröner-Forschungskollegs Magdeburg laden wir Sie herzlich zu diesem Vortrag ein.